Atiq Aribah, Hashim Muhammad Moseeb Ali, Khan Faria W, Bashir Azra, Zafar Asma, Jamil Anum, Chughtai Akhtar S
Pathology, Chughtai Institute of Pathology, Lahore, PAK.
Histopathology, Chughtai Institute of Pathology, Lahore, PAK.
Cureus. 2023 Aug 7;15(8):e43084. doi: 10.7759/cureus.43084. eCollection 2023 Aug.
Introduction () infection is the most common cause of gastritis. The consequences of the persistent infection range from acute ulceration to the development of gastric neoplasia. The purpose of the study is to determine the histopathological pattern of gastritis in gastric biopsies and its association with . Materials and methods This is a retrospective study of all the gastric biopsies received in the Department of Histopathology, Chughtai Institute of Pathology, Lahore, Pakistan from January 12, 2021 to April 10, 2021. Sections were cut from formalin-fixed, paraffin-embedded (FFPE) tissue blocks. Slides were stained with routine, special and immunohistochemical stains. The cases were then blindly reviewed by two pathologists with a special interest in Gastrointestinal Pathology. Microscopic features based on updated Sydney classification were recorded. The collected data were then analyzed by using SPSS version 20 (IBM Corp., Armonk, NY). Results A total of 429 gastric biopsies were examined. Out of which, 202 (47.1%) were male and 227 (52.9%) were female with a female-to-male ratio of 1.2:1. Their ages ranged from 12 to 100 years and a peak in the fourth decade of life with a mean age of 43 years (median age 49 years). Among gastritis, activity was seen in 194 (45%) and chronicity in 237 (55%) cases. was seen in 174 (40.5%) cases and there was a strong statistically significant association between infection and severity of gastritis (p<0.001). Other parameters of Sydney classification, such as atrophic changes, were seen in 144 (33%) cases, and intestinal metaplasia in 10 (2.3%) cases. Conclusion organism was the most common cause of gastritis in our environment. The severity of gastritis is directly related to the infection. If neutrophils are identified on surface epithelium, then should be searched with increased attention on morphology and/or on immunohistochemical stain of . Chronic inflammation and density can also guide treatment which is necessary to avoid complications.
引言 （）感染是胃炎最常见的病因。持续性感染的后果从急性溃疡到胃肿瘤的发生不等。本研究的目的是确定胃活检中胃炎的组织病理学模式及其与（此处原文有缺失内容）的关联。材料与方法 这是一项对2021年1月12日至2021年4月10日期间巴基斯坦拉合尔楚格泰病理研究所组织病理学系接收的所有胃活检标本进行的回顾性研究。切片取自福尔马林固定、石蜡包埋（FFPE）的组织块。玻片用常规、特殊和免疫组织化学染色。然后由两位对胃肠病理学有特殊兴趣的病理学家进行盲法复查。记录基于更新后的悉尼分类的微观特征。然后使用SPSS 20版（IBM公司，纽约州阿蒙克）对收集的数据进行分析。结果 共检查了429例胃活检标本。其中，男性202例（47.1%），女性227例（52.9%），男女比例为1.2:1。他们的年龄在12岁至100岁之间，在生命的第四个十年达到峰值，平均年龄为43岁（中位年龄49岁）。在胃炎病例中，194例（45%）有活动性，237例（55%）有慢性炎症。（此处原文有缺失内容）在174例（40.5%）病例中可见，且（此处原文有缺失内容）感染与胃炎严重程度之间存在强烈的统计学显著关联（p<0.001）。悉尼分类的其他参数，如萎缩性改变，在144例（33%）病例中可见，肠化生在10例（2.3%）病例中可见。结论 （此处原文有缺失内容）微生物是我们环境中胃炎最常见的病因。胃炎的严重程度与（此处原文有缺失内容）感染直接相关。如果在表面上皮发现中性粒细胞，那么应更加关注（此处原文有缺失内容）的形态和/或免疫组织化学染色以寻找（此处原文有缺失内容）。慢性炎症和（此处原文有缺失内容）密度也可指导治疗，这对于避免并发症是必要的。
