Kahlenberg J Michelle, Fox David A
Division of Rheumatology, University of Michigan, 3918 Taubman Center, 1500 East Medical Center, SPC 5358, Ann Arbor, MI 48109-5358, USA.
Hand Clin. 2011 Feb;27(1):11-20. doi: 10.1016/j.hcl.2010.09.002.
Over the past 2 decades, the treatment of rheumatoid arthritis (RA) has been revolutionized by advances in the understanding of its pathologic mechanisms and the development of drugs that target them. These newer medications have shown great promise at improving disease outcomes, but they come with notable side effects that can pose long-term treatment challenges and difficulties in the perioperative arena. In this article, the major manifestations of RA and the current medical options for management are discussed. Complications from treatment are then reviewed, and special consideration is given to perioperative medication recommendations.
在过去的20年里，对类风湿性关节炎（RA）病理机制的深入理解以及针对这些机制研发的药物，彻底改变了RA的治疗方式。这些新型药物在改善疾病预后方面显示出了巨大的潜力，但它们也伴随着显著的副作用，这可能给长期治疗带来挑战，并且在围手术期也存在困难。在本文中，将讨论RA的主要表现以及当前的治疗选择。随后将回顾治疗的并发症，并特别考虑围手术期的用药建议。
