Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain.
Lupus. 2012 Oct;21(12):1359-61. doi: 10.1177/0961203312458841. Epub 2012 Aug 28.
Infections are considered one of the most common causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE), and occasionally can trigger a catastrophic antiphospholipid syndrome (APS). We describe a 22-year-old SLE patient with lupus nephritis under immunosuppressant therapy and asymptomatic carrier of antiphospholipid antibodies, who was admitted with tonsillitis and acute hepatitis, developing multiorgan failure in a few hours. Postmortem examination revealed hepatic necrosis, tonsillitis, pharyngitis and uterine cervicitis caused by herpes simplex virus (HSV) together with microthrombosis in lungs and glomerular arterioles, suggesting the diagnosis of fulminant HSV disseminated infection and catastrophic APS.
感染被认为是全身性红斑狼疮（SLE）患者发病率和死亡率的最常见原因之一，偶尔也会引发灾难性的抗磷脂综合征（APS）。我们描述了一例 22 岁的狼疮肾炎患者，在接受免疫抑制剂治疗和无症状抗磷脂抗体携带者的情况下，因扁桃体炎和急性肝炎入院，几小时内发展为多器官衰竭。尸检显示肝脏坏死、扁桃体炎、咽炎和子宫颈炎由单纯疱疹病毒（HSV）引起，同时肺部和肾小球小动脉存在微血栓形成，提示诊断为暴发性 HSV 播散感染和灾难性 APS。
