Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.
Macromol Biosci. 2012 Oct;12(10):1413-22. doi: 10.1002/mabi.201200171. Epub 2012 Aug 28.
The fouling from four human body fluids - blood plasma, cerebrospinal fluid, urine and saliva - and four animal fluids - foetal bovine and calf sera, egg and milk - relevant to human and veterinary medicine, immunology, biology and diagnostics is assessed on antifouling SAMs and on polymer brushes of oligo(ethylene glycol) methacrylate, 2-hydroxyethyl methacrylate, carboxybetaine acrylamide and N-(2-hydroxypropyl)methacrylamide synthesized via ATRP. While important deposits from the all biofluids are observed on SAMs, a superior resistance is achieved on polymer brushes. Importantly, only poly(CBAA) and poly(HPMA) are capable of resisting the fouling from the most challenging media, blood plasma and eggs.
评估了与人类和兽医医学、免疫学、生物学和诊断学相关的来自四种人体体液（血浆、脑脊液、尿液和唾液）和四种动物体液（胎牛和小牛血清、卵和奶）的污染在防污 SAM 和通过原子转移自由基聚合 (ATRP) 合成的聚 (乙二醇) 甲基丙烯酸酯、2-羟乙基甲基丙烯酸酯、羧酸甜菜碱丙烯酰胺和 N-(2-羟丙基)甲基丙烯酰胺聚合物刷上的情况。虽然在 SAM 上观察到所有生物体液的重要沉积物，但聚合物刷上实现了更高的抗性。重要的是，只有聚 (CBAA) 和聚 (HPMA) 能够抵抗来自最具挑战性的介质（血浆和卵）的污染。
