National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Biomarkers. 2013 Feb;18(1):1-9. doi: 10.3109/1354750X.2012.717105. Epub 2012 Aug 30.
Carcinoma of the gallbladder (GBC) is the most common biliary tree cancer in the world. Beside gallstones, no specific risk factors for GBC are currently established. Several published studies have identified various prognostic gene expression markers in GBC.
The present article reviewed published studies on gene expression biomarkers and gallbladder cancer susceptibility.
We searched the PubMed, Medline, and Embase databases using the search terms "Gallbladder", "cancer/carcinoma", "expression", "genes", "proteins", and "biomarker" updated until June 2012 and limited to English language papers. The online searching was accompanied by checking reference lists from the identified articles for potentially eligible original reports.
Potential GBC biomarkers identified by different studies were summarized.
To infer, the present article highlights a few potential biomarkers in GBC. However, none of the markers identified so far are effective as a routine screening test in GBC.
胆囊癌（GBC）是世界上最常见的胆道系统癌症。除了胆结石之外，目前尚未确定 GBC 的具体危险因素。一些已发表的研究已经确定了 GBC 中各种预后基因表达标志物。
本文综述了已发表的关于基因表达生物标志物与胆囊癌易感性的研究。
我们使用了“胆囊”、“癌症/癌”、“表达”、“基因”、“蛋白质”和“生物标志物”等检索词，在 PubMed、Medline 和 Embase 数据库中进行了检索，并更新至 2012 年 6 月，限定为英文文献。在线搜索的同时，还查阅了从已确定的文章中找到的可能符合条件的原始报告的参考文献列表。
总结了不同研究中确定的潜在 GBC 生物标志物。
目前尚无一种已确定的标志物可作为 GBC 的常规筛查试验。
