J Thorac Dis. 2012 Aug;4(4):358-67. doi: 10.3978/j.issn.2072-1439.2012.07.15.
The aim of the present study is to investigate means for the reduction or even elimination of enhancement kinetic curve errors due to breast motion in order to avoid pitfalls and to increase the sensitivity and specificity of the method.
115 women underwent breast Magnetic Resonance Imaging (MRI). All patients were properly immobilized in a dedicated bilateral phased array coil. A magnetic resonance unit 3-Tesla (Signa, GE Healthcare) was used. The following sequences were applied: (I) axial Τ2-TSE, (II) axial STIR and (III) Vibrant axial T1-weighted fat saturation (six phases). Kinetic curves were derived semi-automatically using the software of the system and manually by positioning the regions of interest (ROI) from stable reference points in all the phases.
376 abnormalities in 115 patients were investigated. In 81 (21.5%) cases, a change of the enhancement kinetic curve type was found when the two different methods were used. In cases of large fatty breasts, a change of the enhancement kinetic curve type in 13 lesions was found. In cases of small and dense breasts, only in 4 lesions the kinetic curve type changed, whereas in cases of small and fatty breasts, the kinetic curve type changed in 64 lesions (50 were observed in left breasts and 14 in right breasts).
The derivation of enhancement kinetic curves should be performed by controlling and verifying that the ROIs lay at the same location of the lesion in all the phases of the dynamic study.
本研究旨在探讨减少甚至消除因乳房运动而导致的增强动力学曲线误差的方法，以避免陷阱，并提高该方法的敏感性和特异性。
115 名女性接受了乳房磁共振成像（MRI）检查。所有患者均在专用双侧相控阵线圈中得到适当固定。使用了一台 3 特斯拉磁共振仪（Signa，GE Healthcare）。应用了以下序列：（I）轴位 T2-TSE、（II）轴位 STIR 和（III）轴向 Vibrant T1 加权脂肪饱和（六个相位）。使用系统软件半自动地和手动地从所有相位中的稳定参考点定位感兴趣区域（ROI）来获得动力学曲线。
在 115 名患者的 376 个异常中进行了研究。当使用两种不同的方法时，81 例（21.5%）发现增强动力学曲线类型发生了变化。在大脂肪乳房的情况下，在 13 个病变中发现了增强动力学曲线类型的变化。在小而密集的乳房中，只有 4 个病变的动力学曲线类型发生了变化，而在小而脂肪的乳房中，64 个病变的动力学曲线类型发生了变化（50 个病变在左侧乳房，14 个在右侧乳房）。
在进行增强动力学曲线的推导时，应通过控制和验证 ROI 位于动态研究的所有相位中的同一病变位置来进行。
