Tomson T, Villén T
Department of Neurology, Söder Hospital, Stockholm, Sweden.
Ther Drug Monit. 1994 Dec;16(6):621-3. doi: 10.1097/00007691-199412000-00016.
A gas-chromatographic method was used to determine plasma concentrations of the ethosuximide enantiomers during three pregnancies in two epileptic women, in samples from the umbilical cord in one, and in breast milk in two patients. The ratio of the two enantiomers of ethosuximide ranged from 1.00 to 1.36 and was apparently unaffected by pregnancy, passage into breast milk, and transfer over the placenta. Hence, determination of total ethosuximide concentrations appear to be sufficient for therapeutic drug monitoring during pregnancy and lactation.
采用气相色谱法测定了两名癫痫女性在三次孕期的乙琥胺对映体的血浆浓度、一名患者脐带血样本中的浓度以及两名患者母乳中的浓度。乙琥胺两种对映体的比例在1.00至1.36之间，显然不受怀孕、进入母乳以及通过胎盘转运的影响。因此，测定乙琥胺的总浓度似乎足以用于孕期和哺乳期的治疗药物监测。
