Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Org Lett. 2012 Sep 21;14(18):4858-61. doi: 10.1021/ol3021918. Epub 2012 Aug 30.
Two synthetic approaches to 4-trifluoromethylsydnones, a novel class of these mesoionic reagents, are reported. These compounds undergo regioselective alkyne cycloaddition reactions, thereby providing a general approach to 5-trifluoromethylpyrazoles. This method has been employed in a short formal synthesis of the herbicide fluazolate.
报告了两种合成 4-三氟甲基-1,2,4-噻唑啉-3-酮（一种新型的介离子试剂）的方法。这些化合物经历区域选择性炔烃环加成反应，从而提供了一种合成 5-三氟甲基吡唑的通用方法。该方法已被应用于除草剂氟唑草酯的短路线合成中。
