Nieuwesteeg Anke, Pouwer Frans, van der Kamp Rozemarijn, van Bakel Hedwig, Aanstoot Henk-Jan, Hartman Esther
Developmental Psychology/Tilburg University, Room number: P 707, P.O. Box 90153, 5000 LE Tilburg, The Netherlands.
Curr Diabetes Rev. 2012 Nov;8(6):434-43. doi: 10.2174/157339912803529850.
Children with type 1 diabetes mellitus (T1DM) have to deal with a complex and demanding daily treatment regime which can have a negative impact on the quality of life (QoL) of these patients. The objective of the present study is to review studies that have compared generic quality of life of children and adolescents with T1DM with that of healthy peers. In addition, we will examine whether QoL differs between boys and girls, and across different developmental stages.
A systematic literature search using PubMed was conducted for the years 2000 through May 2012. 17 studies were eligible for the current review. Effect sizes were computed to estimate the effects of having T1DM on QoL in children and adolescents.
Although individual studies reported small to moderate effect sizes on the distinct QoL-domains, the weighted effect sizes across all studies indicated no differences in QoL-domains between children and adolescents with T1DM and healthy controls. However, disease-specific problems were certainly present. Girls with T1DM reported lower generic and disease-specific QoL than boys with T1DM. Relationships between age and generic or disease-specific QoL remained unclear.
Although children and adolescents with T1DM have to live with a demanding treatment regime, overall results revealed that their generic QoL is not impaired compared to healthy peers. However, disease-specific QoL problems, including a negative impact of diabetes on daily functioning, and diabetes-related worries were certainly present. Longitudinal research is needed in order to provide tailored care for children of all ages with T1DM.
1型糖尿病（T1DM）患儿必须应对复杂且要求严格的日常治疗方案，这可能会对这些患者的生活质量（QoL）产生负面影响。本研究的目的是回顾比较T1DM儿童和青少年与健康同龄人一般生活质量的研究。此外，我们将研究生活质量在男孩和女孩之间以及不同发育阶段是否存在差异。
使用PubMed对2000年至2012年5月进行了系统的文献检索。17项研究符合当前综述的要求。计算效应量以估计患T1DM对儿童和青少年生活质量的影响。
尽管个别研究报告了在不同生活质量领域有小到中等的效应量，但所有研究的加权效应量表明，T1DM儿童和青少年与健康对照组在生活质量领域没有差异。然而，特定疾病的问题确实存在。患有T1DM的女孩报告的一般生活质量和特定疾病生活质量低于患有T1DM的男孩。年龄与一般或特定疾病生活质量之间的关系仍不明确。
尽管患有T1DM的儿童和青少年必须忍受严格的治疗方案，但总体结果显示，与健康同龄人相比，他们的一般生活质量并未受损。然而，特定疾病的生活质量问题肯定存在，包括糖尿病对日常功能的负面影响以及与糖尿病相关的担忧。需要进行纵向研究，以便为所有年龄段的T1DM儿童提供个性化护理。
