Fayyaz Farimah, Mardi Parham, Sobhani Sahar, Sokoty Leily, Aghamahdi Fatemeh, Qorbani Mostafa
Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
J Diabetes Metab Disord. 2023 Nov 27;23(1):783-788. doi: 10.1007/s40200-023-01351-w. eCollection 2024 Jun.
Psychological factors and patients' health-related quality of life (HRQOL) affect the outcome of patients with type 1 diabetes mellitus (T1DM). In this study, we aimed to determine the HRQOL status in patients with T1DM and its association with glycemic control and medication adherence.
In this cross-sectional study, 227 T1DM patients were selected from the diabetes clinic, Imam Ali Hospital, Alborz University of Medical Sciences, and the Gabric database registry from 2020 to 2022. Demographic and diabetes characteristic checklist, medication adherence questionnaire (8-item Morisky Medication Adherence Scale (MMAS)), and QOL questionnaires (Short-Form-12 and PedsQL) were filled. Independent sample T-test was used to assess mean of QOL subscales with glycemic control and medication adherence. A logistic regression model was used to evaluate the association between glycemic control and medication adherence with QOl.
Overall QOL scores in adults and children were 33.4 ± 7.1 based on Short-Form-12 and 76.2 ± 17.8 based on PedsQL, respectively. It was demonstrated that adults with Moderate/High adherence had higher QOL (p-value = 0.007). Likewise, Children with good glycemic control had higher psychosocial health scores (0.048). Logistic regression analysis did not reveal a significant association between adherence and QOL or Glycemic control and QOL in both adjusted and crude models.
Better glycemic control and medication adherence in children and adults, respectively, are related to the psychological aspects of QOL. We suggest that emotional intelligence, which is replaced by other predictors during adulthood, may contribute to glycemic control in children in the early years following diagnosis.
心理因素和患者的健康相关生活质量（HRQOL）会影响1型糖尿病（T1DM）患者的治疗结果。在本研究中，我们旨在确定T1DM患者的HRQOL状况及其与血糖控制和药物依从性的关联。
在这项横断面研究中，从2020年至2022年，从阿尔伯兹医科大学伊玛目阿里医院的糖尿病诊所以及加布里克数据库登记处选取了227例T1DM患者。填写了人口统计学和糖尿病特征清单、药物依从性问卷（8项Morisky药物依从性量表（MMAS））以及生活质量问卷（简短形式-12和儿童生活质量量表（PedsQL））。采用独立样本T检验来评估生活质量子量表与血糖控制和药物依从性的均值。使用逻辑回归模型来评估血糖控制和药物依从性与生活质量之间的关联。
基于简短形式-12，成人和儿童的总体生活质量得分分别为33.4±7.1，基于儿童生活质量量表（PedsQL）为76.2±17.8。结果表明，中度/高度依从的成人具有更高的生活质量（p值=0.007）。同样，血糖控制良好的儿童具有更高的心理社会健康得分（0.048）。逻辑回归分析在调整模型和原始模型中均未揭示依从性与生活质量或血糖控制与生活质量之间的显著关联。
儿童和成人中更好的血糖控制和药物依从性分别与生活质量的心理方面相关。我们建议，在成年期被其他预测因素取代的情商，可能在诊断后的早期对儿童的血糖控制有帮助。
