Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Biochemistry. 2012 Sep 25;51(38):7580-7. doi: 10.1021/bi300629f. Epub 2012 Sep 12.
Depolymerizing cytoskeletal filaments are involved in cell division, cell motility, and other cellular functions. Understanding the dynamics of depolymerization is as important as understanding the dynamics of polymerization. We study nonequilibrium depolymerization of actin filaments using a simple two-state model. We show that the polymerization history influences the dynamics of depolymerization as well as the length fluctuations during depolymerization. We also simulate depolymerization under different experimentally feasible conditions. Under conditions of constant concentration, we show that the depolymerization happens in two regimes. Under the conditions of mass conservation, the depolymerization can have three regimes.
解聚细胞骨架丝参与细胞分裂、细胞运动和其他细胞功能。了解解聚的动力学与了解聚合的动力学同样重要。我们使用简单的两态模型研究肌动蛋白丝的非平衡解聚。我们表明聚合历史会影响解聚的动力学以及解聚过程中的长度波动。我们还模拟了不同实验可行条件下的解聚。在恒定浓度条件下，我们表明解聚发生在两个区域。在质量守恒条件下，解聚可以有三个区域。
