Ye Lei, Swingen Cory, Zhang Jianyi
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Curr Cardiol Rev. 2013 Feb 1;9(1):63-72. doi: 10.2174/157340313805076278.
Induced pluripotent stem (iPS) cells, are a type of pluripotent stem cell derived from adult somatic cells. They have been reprogrammed through inducing genes and factors to be pluripotent. iPS cells are similar to embryonic stem (ES) cells in many aspects. This review summarizes the recent progresses in iPS cell reprogramming and iPS cell based therapy, and describe patient specific iPS cells as a disease model at length in the light of the literature. This review also analyzes and discusses the problems and considerations of iPS cell therapy in the clinical perspective for the treatment of disease.
诱导多能干细胞（iPS细胞）是一类源自成体细胞的多能干细胞。它们通过导入基因和因子被重编程为多能性细胞。iPS细胞在许多方面与胚胎干细胞（ES细胞）相似。本文综述了iPS细胞重编程和基于iPS细胞的治疗的最新进展，并结合文献详细描述了患者特异性iPS细胞作为疾病模型的情况。本文还从临床角度分析和讨论了iPS细胞治疗疾病时存在的问题及注意事项。
