College of Pharmacy, Dongguk University, Goyang, Gyeonggi-do, Republic of Korea.
Biochem Pharmacol. 2012 Nov 15;84(10):1351-8. doi: 10.1016/j.bcp.2012.08.012. Epub 2012 Aug 23.
Severe acute respiratory syndrome (SARS) was the first pandemic in the 21st century to claim more than 700 lives worldwide. However, effective anti-SARS vaccines or medications are currently unavailable despite being desperately needed to adequately prepare for a possible SARS outbreak. SARS is caused by a novel coronavirus, and one of its components, a viral helicase, is emerging as a promising target for the development of chemical SARS inhibitors. In the following review, we describe the characterization, family classification, and kinetic movement mechanisms of the SARS coronavirus (SCV) helicase-nsP13. We also discuss the recent progress in the identification of novel chemical inhibitors of nsP13 in the context of our recent discovery of the strong inhibition of the SARS helicase by natural flavonoids, myricetin and scutellarein. These compounds will serve as important resources for the future development of anti-SARS medications.
严重急性呼吸综合征（SARS）是 21 世纪首次在全球范围内造成 700 多人死亡的大流行疾病。然而，尽管迫切需要有效的抗 SARS 疫苗或药物来充分准备可能的 SARS 爆发，但目前仍无法获得。SARS 是由一种新型冠状病毒引起的，其成分之一，一种病毒解旋酶，作为开发化学 SARS 抑制剂的有希望的靶标正在出现。在下面的综述中，我们描述了 SARS 冠状病毒（SCV）解旋酶-nsP13 的特征、家族分类和动力学运动机制。我们还讨论了最近在鉴定新型化学抑制剂方面的进展，这些抑制剂是基于我们最近发现的天然类黄酮杨梅素和桑色素对 SARS 解旋酶的强烈抑制作用。这些化合物将成为未来开发抗 SARS 药物的重要资源。
