VDAC3 通过将 Mps1 靶向到中心体来调节中心体的组装。
VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.
机构信息
Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
出版信息
Cell Cycle. 2012 Oct 1;11(19):3666-78. doi: 10.4161/cc.21927. Epub 2012 Aug 30.
Abstract
Centrioles are duplicated during S-phase to generate the two centrosomes that serve as mitotic spindle poles during mitosis. The centrosomal pool of the Mps1 kinase is important for centriole assembly, but how Mps1 is delivered to centrosomes is unknown. Here we have identified a centrosome localization domain within Mps1 and identified the mitochondrial porin VDAC3 as a protein that binds to this region of Mps1. Moreover, we show that VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
摘要
中心体在 S 期复制，产生两个中心体，作为有丝分裂纺锤体的两极。Mps1 激酶的中心体池对于中心体组装很重要，但 Mps1 如何递送到中心体尚不清楚。在这里，我们在 Mps1 内鉴定出一个中心体定位结构域，并鉴定出线粒体孔蛋白 VDAC3 作为与 Mps1 此区域结合的蛋白。此外，我们表明 VDAC3 存在于母中心粒上，并通过将 Mps1 招募到中心体来调节中心体组装。
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