自噬调控作为一种治疗多种疾病的潜在靶点。
Autophagy modulation as a potential therapeutic target for diverse diseases.
机构信息
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
出版信息
Nat Rev Drug Discov. 2012 Sep;11(9):709-30. doi: 10.1038/nrd3802.
Abstract
Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation.
摘要
自噬是一种重要的、保守的溶酶体降解途径，通过清除蛋白质聚集体和受损细胞器来控制细胞质的质量。自噬体双层膜包裹细胞质的一部分，这一过程开始，随后这些小泡与溶酶体融合，并降解自噬内容物。除了其重要的动态平衡作用外，这种降解途径还参与各种人类疾病，包括代谢疾病、神经退行性疾病、癌症和传染病。本文概述了自噬的机制和调控、该途径在疾病中的作用以及治疗调节的策略。
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