State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
Org Lett. 2012 Sep 21;14(18):4966-9. doi: 10.1021/ol302372p. Epub 2012 Aug 31.
An unprecedented palladium-catalyzed cyanation of aromatic C-H bonds by using tertiary amine derived isocyanide as a novel cyano source was developed. Cu(TFA)(2) was used as a requisite stoichiometric oxidant. Mechanistic studies suggest that a tertiary carbon cation-based intermediate is involved following the C-N bond breakage.
开发了一种前所未有的钯催化芳环 C-H 键氰化反应，使用叔胺衍生的异氰化物作为新型氰源。Cu(TFA)2 用作必需的化学计量氧化剂。机理研究表明，在 C-N 键断裂后，涉及到基于叔碳阳离子的中间体。
