有经验的马拉松跑者中心律失常和无症状性脑损伤的发生率：柏林跑步节拍研究的原理、设计和基线数据。
Rate of cardiac arrhythmias and silent brain lesions in experienced marathon runners: rationale, design and baseline data of the Berlin Beat of Running study.
机构信息
Department of Neurology, Charité Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
出版信息
BMC Cardiovasc Disord. 2012 Aug 31;12:69. doi: 10.1186/1471-2261-12-69.
BACKGROUND
Regular exercise is beneficial for cardiovascular health but a recent meta-analysis indicated a relationship between extensive endurance sport and a higher risk of atrial fibrillation, an independent risk factor for stroke. However, data on the frequency of cardiac arrhythmias or (clinically silent) brain lesions during and after marathon running are missing.
METHODS/DESIGN: In the prospective observational "Berlin Beat of Running" study experienced endurance athletes underwent clinical examination (CE), 3 Tesla brain magnetic resonance imaging (MRI), carotid ultrasound imaging (CUI) and serial blood sampling (BS) within 2-3 days prior (CE, MRI, CUI, BS), directly after (CE, BS) and within 2 days after (CE, MRI, BS) the 38th BMW BERLIN-MARATHON 2011. All participants wore a portable electrocardiogram (ECG)-recorder throughout the 4 to 5 days baseline study period. Participants with pathological MRI findings after the marathon, troponin elevations or detected cardiac arrhythmias will be asked to undergo cardiac MRI to rule out structural abnormalities. A follow-up is scheduled after one year.
RESULTS
Here we report the baseline data of the enrolled 110 athletes aged 36-61 years. Their mean age was 48.8 ± 6.0 years, 24.5% were female, 8.2% had hypertension and 2.7% had hyperlipidaemia. Participants have attended a mean of 7.5 ± 6.6 marathon races within the last 5 years and a mean of 16 ± 36 marathon races in total. Their weekly running distance prior to the 38th BMW BERLIN-MARATHON was 65 ± 17 km. Finally, 108 (98.2%) Berlin Beat-Study participants successfully completed the 38th BMW BERLIN-MARATHON 2011.
DISCUSSION
Findings from the "Berlin Beats of Running" study will help to balance the benefits and risks of extensive endurance sport. ECG-recording during the marathon might contribute to identify athletes at risk for cardiovascular events. MRI results will give new insights into the link between physical stress and brain damage.
TRIAL REGISTRATION
clinicaltrials.gov NCT01428778.
背景
定期运动有益于心血管健康，但最近的一项荟萃分析表明，广泛的耐力运动与心房颤动风险增加有关，心房颤动是中风的一个独立危险因素。然而，关于马拉松跑步过程中和之后心律失常或（临床无症状）脑损伤的频率的数据尚不清楚。
方法/设计：在前瞻性观察性的“柏林跑步节拍”研究中，经验丰富的耐力运动员在 2011 年第 38 届宝马柏林马拉松赛之前的 2-3 天内（CE、MRI、CUI、BS）、直接之后（CE、BS）和之后的 2 天内（CE、MRI、BS）接受临床检查（CE）、3 特斯拉脑磁共振成像（MRI）、颈动脉超声成像（CUI）和连续采血（BS）。所有参与者在整个 4-5 天的基线研究期间都佩戴便携式心电图（ECG）记录仪。马拉松赛后出现 MRI 病理发现、肌钙蛋白升高或发现心律失常的参与者将被要求进行心脏 MRI 以排除结构异常。计划在一年后进行随访。
结果
这里我们报告了入组的 110 名年龄在 36-61 岁的运动员的基线数据。他们的平均年龄为 48.8 ± 6.0 岁，24.5%为女性，8.2%患有高血压，2.7%患有高脂血症。参与者在过去 5 年内平均参加了 7.5 ± 6.6 次马拉松比赛，总共参加了 16 ± 36 次马拉松比赛。他们在参加第 38 届宝马柏林马拉松赛之前每周的跑步距离为 65 ± 17 公里。最后，108 名（98.2%）柏林节拍研究参与者成功完成了 2011 年第 38 届宝马柏林马拉松赛。
讨论
“柏林奔跑节拍”研究的结果将有助于平衡广泛耐力运动的益处和风险。马拉松比赛期间的心电图记录可能有助于确定心血管事件风险高的运动员。MRI 结果将为身体应激与脑损伤之间的联系提供新的见解。
试验注册
clinicaltrials.gov NCT01428778。
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