Yang Xue-Xi, Li Fen-Xia, Zhou Cui-Ping, Hu Ni-Ya, Wu Ying-Shong, Li Ming
School of Biotechnology, Southern Medical University, Guangzhou, China.
Asian Pac J Cancer Prev. 2012;13(6):2519-22. doi: 10.7314/apjcp.2012.13.6.2519.
Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophageal squamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22 and 10q23 are susceptibility-associated regions for GC. However, this has not been confirmed in southern Chinese populations. The aim of this study was to investigate whether these polymorphisms at 1q22 and 10q23 are associated with the risk of GC in a southern Chinese population.
We selected seven top significant associated single nucleotide polymorphisms (SNPs) at 1q22 and 10q23 and conducted a population-based case- control study in a southern Chinese population. Genotypes were determined using MassARRAYTM system (Sequenome, San Diego, CA).
Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model. Logistic regression models adjusted for age and sex showed that rs4072037 AG and GG (OR=0.64, P=0.017, compared with AA) and rs4460629 CT and TT (OR=0.54, P=0.0016, compared with TT) significantly reduced the risk of GC. However, no significant results for the five SNPs at 10q23 were obtained in this study.
These outcomes indicate that 1q22 is associated with GC susceptibility in this southern Chinese population, while an association for the locus at 10q23 was not confirmed.
来自近期对生活在中国中北部太行山区的中国人进行的胃癌（GC）和食管鳞状细胞癌全基因组关联研究的数据表明，1q22和10q23是GC的易感相关区域。然而，这在中国南方人群中尚未得到证实。本研究的目的是调查1q22和10q23处的这些多态性是否与中国南方人群中GC的风险相关。
我们在1q22和10q23处选择了7个高度显著相关的单核苷酸多态性（SNP），并在中国南方人群中进行了一项基于人群的病例对照研究。使用MassARRAYTM系统（Sequenome，圣地亚哥，加利福尼亚州）确定基因型。
1q22处的两个SNP，rs4072037和rs4460629，与GC风险降低显著相关，最符合显性遗传模型。经年龄和性别调整的逻辑回归模型显示，rs4072037的AG和GG（与AA相比，OR = 0.64，P = 0.017）以及rs4460629的CT和TT（与CC相比，OR = 0.54，P = 0.0016）显著降低了GC风险。然而，本研究中10q23处的5个SNP未获得显著结果。
这些结果表明，1q22与中国南方人群中的GC易感性相关，而10q23位点的相关性未得到证实。
