Chen Qingfa, Wang Yu, Xu Yan, Lin Hai, Xue Fangxi, Chen Xingtian
Department of Gastroenterology, Linyi Central Hospital, Linyi, China.
Mol Genet Genomic Med. 2019 Apr;7(4):e00589. doi: 10.1002/mgg3.589. Epub 2019 Feb 19.
The relationship between phospholipase C ε-1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta-analysis to obtain a more credible conclusion.
PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72-0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12-1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11-1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74-0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10-1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78-0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians.
Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
尽管进行了广泛研究，但磷脂酶Cε-1（PLCE1）rs2274223变异与消化道癌之间的关系仍无定论。因此，我们进行了这项荟萃分析以获得更可靠的结论。
系统检索了PubMed、Medline和Embase。计算优势比（OR）和95%置信区间（CI）。
最终纳入27项研究。汇总分析表明，在总体人群中，PLCE1 rs2274223变异与食管癌发生可能性显著相关（显性模型：p < 0.001，OR = 0.77，95% CI 0.72 - 0.83；隐性模型：p < 0.001，OR = 1.28，95% CI 1.12 - 1.45；加性模型：p < 0.001，OR = 1.20，95% CI 1.11 - 1.29；等位基因模型：p < 0.001，OR = 0.80，95% CI 0.74 - 0.88）以及与胃癌发生可能性显著相关（隐性模型：p = 0.001，OR = 1.27，95% CI 1.10 - 1.47；等位基因模型：p = 0.03，OR = 0.88，95% CI 0.78 - 0.98）。进一步的亚组分析显示，阳性结果主要由东亚人群驱动。然而，在高加索人和西亚人群中未检测到阳性结果。
我们的研究结果表明，PLCE1 rs2274223变异可能是东亚人群食管癌和胃癌有前景的遗传生物标志物。
