School of Biotechnology, Southern Medical University, Guangzhou 510515, China.
Mol Biol Rep. 2012 Oct;39(10):9557-62. doi: 10.1007/s11033-012-1820-8. Epub 2012 Jun 28.
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population. These findings were confirmed in a subsequent independent study. However, it remains unknown whether these loci are associated with an increased risk of colorectal cancer (CRC). This study was to test whether the seven single nucleotide polymorphisms (SNPs) associated with GC were also associated with CRC in a Chinese population. The seven SNPs were genotyped using MassARRAY system. Allelic, genotypic, and haplotypic associations of the SNPs with CRC were investigated using χ(2) tests and logistic regression analysis. The SNPs rs3765524 and rs2274223, located on 10q23, were found to have significant protective effects against CRC, with equal odds ratios per allele. The two SNPs located on 1q22 (rs4072037 and rs4460629) showed a weak association with CRC. No significant association was identified with CRC for the remaining three SNPs located on 10q23 (rs753724, rs11187842, and rs3781264). These results suggest that rs3765524 and rs2274223 on 10q23 are associated with a protective effect against CRC in a Chinese population.
最近，一项针对胃癌（GC）的全基因组关联研究报告了七个遗传变异（位于 1q22 的 rs4072037 和 rs4460629；位于 10q23 的 rs753724、rs11187842、rs3765524、rs2274223 和 rs3781264）与中国人群中 GC 的显著关联。这些发现随后在一项独立的研究中得到了证实。然而，这些位点是否与结直肠癌（CRC）的风险增加有关尚不清楚。本研究旨在检验与 GC 相关的七个单核苷酸多态性（SNPs）是否也与中国人群中的 CRC 相关。使用 MassARRAY 系统对这七个 SNPs 进行基因分型。使用 χ(2)检验和逻辑回归分析，研究了 SNP 与 CRC 的等位、基因型和单倍型关联。位于 10q23 的 rs3765524 和 rs2274223 两个 SNP 与 CRC 有显著的保护作用，每个等位基因的优势比相等。位于 1q22 的两个 SNP（rs4072037 和 rs4460629）与 CRC 有微弱的关联。位于 10q23 的其余三个 SNP（rs753724、rs11187842 和 rs3781264）与 CRC 无显著关联。这些结果表明，位于 10q23 的 rs3765524 和 rs2274223 与中国人群 CRC 的保护作用有关。
