Omar M A, Hammond M G, Desai R K, Motala A A, Aboo N, Seedat M A
Department of Medicine, University of Natal, Durban, South Africa.
Clin Immunol Immunopathol. 1990 Jan;54(1):98-102. doi: 10.1016/0090-1229(90)90009-f.
A study was done to evaluate the relationship between Graves' disease and the HLA system in South African Blacks of Zulu descent. One hundred and three patients with Graves' disease and 1416 control subjects were typed for HLA A, B, and C antigens while HLA DR antigens were done on 63 of the former and 330 of the latter. There was a significant increase in the frequency of HLA DR3 in patients compared to control subjects (57.1% vs 36.1%; P corrected = 0.014). A relationship was also seen at the DR1 locus (14.3% vs 4.6%; P corrected = 0.023).
一项研究旨在评估祖鲁族裔南非黑人中格雷夫斯病与HLA系统之间的关系。对103例格雷夫斯病患者和1416名对照受试者进行了HLA A、B和C抗原分型，同时对其中63例患者和330名对照受试者进行了HLA DR抗原分型。与对照受试者相比，患者中HLA DR3的频率显著增加（57.1%对36.1%；校正P值=0.014）。在DR1位点也观察到一种关系（14.3%对4.6%；校正P值=0.023）。
