Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA.
Bone. 2013 Jun;54(2):258-63. doi: 10.1016/j.bone.2012.08.121. Epub 2012 Aug 23.
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine RANKL involved in osteoclast formation in cancellous bone. The goal of this review is to discuss these and other studies that reveal mechanisms whereby osteocytes control osteoclast formation and thus bone resorption.
多项证据支持这样一种观点，即骨细胞作为骨骼中的机械感受器发挥作用，它们通过表达 Wnt 拮抗剂骨硬化蛋白来控制骨形成，部分原因在于表达 Wnt 拮抗剂骨硬化蛋白。然而，骨细胞在控制骨吸收中的作用尚不清楚。最近的研究表明，骨细胞是参与松质骨破骨细胞形成的细胞因子 RANKL 的主要来源。本综述的目的是讨论这些和其他研究，这些研究揭示了骨细胞控制破骨细胞形成从而控制骨吸收的机制。
