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PGC-1 蛋白与心力衰竭。

PGC-1 proteins and heart failure.

机构信息

Division of Endocrinology, Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

出版信息

Trends Cardiovasc Med. 2012 May;22(4):98-105. doi: 10.1016/j.tcm.2012.07.003. Epub 2012 Aug 29.

DOI:10.1016/j.tcm.2012.07.003
PMID:22939990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3466400/
Abstract

The transcriptional coactivators PGC-1α and PGC-1β are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1α and PGC-1β gene expression. Maintaining expression of PGC-1α and -β preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.

摘要

转录共激活因子 PGC-1α 和 PGC-1β 是氧化磷酸化和脂肪酸氧化基因表达的主要调节因子。压力超负荷肥大和心力衰竭与 PGC-1α 和 PGC-1β 基因表达受抑制有关。保持 PGC-1α 和 -β 的表达可在工作负荷病理性增加时维持收缩功能。在这里，我们讨论了在压力超负荷肥大和心力衰竭条件下 PGC-1 蛋白的调节。

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本文引用的文献

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Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.核酸内切酶 G 是心脏肥大和线粒体功能的一个新决定因素。
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AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.AMP 激活的蛋白激酶-α2 调节代谢转录因子雌激素相关受体-α的表达，该因子与心力衰竭的发展有关。
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PGC-1β regulates angiogenesis in skeletal muscle.PGC-1β 调节骨骼肌中的血管生成。
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