Nastruzzi C, Walde P, Menegatti E, Gambari R
Institut fur Polymere, ETH-Zentrum, Zurich, Switzerland.
FEBS Lett. 1990 Jan 1;259(2):293-6. doi: 10.1016/0014-5793(90)80030-m.
The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10-20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids.
在体外培养的肿瘤细胞系上分析了脂质体相关视黄酸的活性，并将其与游离视黄酸的抗增殖作用进行了比较。结果发现，脂质体相关视黄酸在抑制白血病和黑色素瘤细胞系的体外细胞生长方面的活性比游离视黄酸高约300倍。在将该化合物与空脂质体预混合后，视黄酸的活性也有所提高（10 - 20倍），这表明视黄酸能有效地与脂质体相互作用，这可能有助于类视黄醇的溶解性和细胞摄取。
