Nastruzzi C, Walde P, Menegatti E, Gambari R
Institut für Polymere, Eidgenössische Technische Hochschule, Zürich, Switzerland.
Biochim Biophys Acta. 1989 Sep 4;1013(1):36-41. doi: 10.1016/0167-4889(89)90124-9.
It is known that iron chelators (such as desferrioxamine) are potent inhibitors of both cell proliferation and erythroid differentiation. We have shown with in vitro studies that in the case of tumor cells desferrioxamine is even more efficient in inhibiting cell proliferation when entrapped in liposomes consisting of egg yolk phosphatidylcholine. At the same time liposome-entrapped desferrioxamine retains only a slight effect on hexamethylenebisacetamide induction of erythroid differentiation and hemoglobin accumulation of murine erythroleukemic Friend cells. Based on these findings, we propose liposome-entrapped desferrioxamine as potential antineoplastic agent as well as a specific chemical for the study of both iron metabolism and distribution in normal and neoplastic cells. In addition, unlike free desferrioxamine, the liposome-entrapped drug could also be used in combination with inducers of differentiation. With respect to this issue, it is possible that liposome-entrapped desferrioxamine, might permit erythroid differentiation of both neoplastic cells as well as normal stem cells.
已知铁螯合剂（如去铁胺）是细胞增殖和红系分化的有效抑制剂。我们的体外研究表明，对于肿瘤细胞，当去铁胺包裹于由蛋黄磷脂酰胆碱组成的脂质体中时，其抑制细胞增殖的效率更高。同时，脂质体包裹的去铁胺对六亚甲基双乙酰胺诱导的小鼠红白血病Friend细胞的红系分化和血红蛋白积累仅具有轻微影响。基于这些发现，我们提出脂质体包裹的去铁胺可作为潜在的抗肿瘤药物，以及用于研究正常细胞和肿瘤细胞中铁代谢及分布的特定化学品。此外，与游离去铁胺不同，脂质体包裹的药物还可与分化诱导剂联合使用。关于这个问题，脂质体包裹的去铁胺有可能使肿瘤细胞和正常干细胞都发生红系分化。
