Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, United States; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Neuropsychologia. 2012 Oct;50(12):2880-2886. doi: 10.1016/j.neuropsychologia.2012.08.011. Epub 2012 Aug 23.
Accumulating evidence suggests that subjective cognitive complaints (SCC) may indicate subtle cognitive decline characteristic of individuals with preclinical Alzheimer's disease (AD). In this study, we sought to build upon previous studies by associating SCC and amyloid-β deposition using positron emission tomography with Pittsburgh Compound B (PiB-PET) in cognitively normal older individuals. One-hundred thirty one subjects (mean age 73.5±6) were administered three subjective cognitive questionnaires and a brief neuropsychological battery. A relationship between a subjective memory complaints composite score and cortical PiB binding was found to be significant, even after controlling for depressive symptoms. By contrast, there were no significant relationships between objective cognitive measures of memory and executive functions and cortical PiB binding. Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment.
越来越多的证据表明，主观认知抱怨（SCC）可能表明存在临床前阿尔茨海默病（AD）特征的个体的微妙认知下降。在这项研究中，我们试图通过在认知正常的老年人中使用正电子发射断层扫描与匹兹堡化合物 B（PiB-PET）将 SCC 与淀粉样蛋白-β沉积联系起来，在此基础上进行研究。对 131 名受试者（平均年龄 73.5±6）进行了三项主观认知问卷和一项简短的神经心理学测试。即使在控制了抑郁症状之后，仍发现主观记忆抱怨综合评分与皮质 PiB 结合之间存在显着关系。相比之下，记忆和执行功能的客观认知测量与皮质 PiB 结合之间没有显着关系。我们的研究表明，SCC 可能是 AD 病理学的早期指标，在出现明显的客观损害之前即可检测到。
