Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Braunschweig, Germany.
Food Chem Toxicol. 2012 Dec;50(12):4405-11. doi: 10.1016/j.fct.2012.08.020. Epub 2012 Aug 23.
The plasma elimination kinetics of the Fusarium toxin deoxynivalenol (DON) was investigated in male castrated pigs (40.4±3.7 kg) when infused intravenously either alone (100 μg/kg/h, n=6) or together with lipopolysaccharides (LPS, 7.5 μg/kg/h, n=6). The maximum DON concentration after one hour of infusion was significantly higher by 61% in the DON+LPS Group compared to pigs infused with DON alone. The area under the plasma DON concentration vs. time curve of the DON+LPS Group was approximately twice as high as that of the DON Group after 24h while the initial (0.63 vs. 0.6 h) and terminal half-lifes (2.97 vs. 2.30 h) remained uninfluenced. The apparent volume of distribution and the plasma clearance were significantly lower for the DON+LPS Group compared to the DON Group (2.14 vs. 1.45 L/kg and 11.9 vs. 5.87 mL/kg/min). Glucuronidated DON seemed to persist longer in the DON+LPS Group. In conclusion, clearance of DON was decreased during an LPS induced acute phase reaction in pigs. Whether the higher plasma DON concentrations in endotoxemic pigs are due to a hemodynamically associated longer persistence of the DON glucuronide or because of an altered glucuronidation activity needs to be examined further.
当雄性去势猪（40.4±3.7kg）静脉内单独输注（100μg/kg/h，n=6）或同时输注脂多糖（LPS，7.5μg/kg/h，n=6）时，研究了镰刀菌毒素脱氧雪腐镰刀菌烯醇（DON）的血浆消除动力学。输注 1 小时后，DON+LPS 组的 DON 最大浓度比单独输注 DON 的猪高 61%。DON+LPS 组在 24 小时后的血浆 DON 浓度-时间曲线下面积（AUC）大约是 DON 组的两倍，而初始半衰期（0.63 与 0.6 h）和终末半衰期（2.97 与 2.30 h）不受影响。与 DON 组相比，DON+LPS 组的表观分布容积和血浆清除率显著降低（2.14 与 1.45 L/kg 和 11.9 与 5.87 mL/kg/min）。DON 结合物似乎在 DON+LPS 组中持续时间更长。总之，在 LPS 诱导的猪急性期反应中，DON 的清除率降低。内毒素血症猪血浆中更高的 DON 浓度是由于 DON 葡萄糖醛酸结合物的血流动力学相关持久性延长，还是由于葡萄糖醛酸化活性改变，需要进一步研究。
