School of Optometry, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung City 402, Taiwan, ROC.
Exp Eye Res. 2012 Oct;103:71-7. doi: 10.1016/j.exer.2012.08.001. Epub 2012 Aug 24.
The present study examined the protective effects of taurine on alloxan-induced diabetic cataracts and lens damage in male New Zealand White rabbits. The animals were randomly divided into three treatment groups: (1) normal control (vehicle administration); (2) diabetes (100 mg/kg alloxan administration); and (3) diabetes + taurine (1% [w/v] taurine dissolved in drinking water and alloxan administration). The results showed that alloxan-induced diabetes caused significant (p < 0.05) hyperglycemia, hyperopic refraction shifts, cataract formation and lens damage compared with the normal control group. In contrast, the administration of taurine for 24 weeks significantly ameliorated the alloxan-induced elevated levels of blood glucose, level of hyperopic refraction error shifts in the eyes and progression of diabetic cataract formation in the lens in rabbits. Moreover, histopathology showed that the taurine supplement reduced the incidence of lens lesions induced by hyperglycemia. Overall, the studies demonstrate that taurine exhibits potent protective effects against alloxan-induced diabetic cataracts and refraction changes in rabbits.
本研究探讨了牛磺酸对新西兰白兔丙烯醛诱导型糖尿病性白内障及晶状体损伤的保护作用。将动物随机分为三组：（1）正常对照组（给予载体）；（2）糖尿病组（给予 100mg/kg 丙烯醛）；（3）糖尿病+牛磺酸组（1%[w/v]牛磺酸溶于饮用水并给予丙烯醛）。结果表明，与正常对照组相比，丙烯醛诱导的糖尿病导致明显的（p＜0.05）高血糖、远视折射移位、白内障形成和晶状体损伤。相比之下，24 周的牛磺酸给药可显著改善丙烯醛诱导的兔血糖升高、远视折射误差水平升高以及晶状体糖尿病性白内障形成的进展。此外，组织病理学显示，牛磺酸补充剂降低了高血糖诱导的晶状体病变的发生率。总之，这些研究表明牛磺酸对丙烯醛诱导的兔糖尿病性白内障和折射变化具有显著的保护作用。
