Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 6707 Democracy Blvd, Rm. 787, MSC 5460, Bethesda, MD 20892-5460, USA.
Mamm Genome. 2012 Oct;23(9-10):623-31. doi: 10.1007/s00335-012-9425-z. Epub 2012 Sep 1.
The Mouse Metabolic Phenotyping Centers (MMPCs) were founded in 2001 by the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high-quality phenotyping services for mouse models of diabetes, obesity, and their complications. The intent is to allow researchers to take optimum advantage of the many new mouse models produced in labs and in high-throughput public efforts. The six MMPCs are located at universities around the country and perform complex metabolic tests in intact mice and hormone and analyte assays in tissues on a fee-for-service basis. Testing is subsidized by the NIH in order to reduce the barriers for mouse researchers. Although data derived from these tests belong to the researcher submitting mice or tissues, these data are archived after publication in a public database run by the MMPC Coordinating and Bioinformatics Unit. It is hoped that data from experiments performed in many mouse models of metabolic diseases, using standard protocols, will be useful in understanding the nature of these complex disorders. The current areas of expertise include energy balance and body composition, insulin action and secretion, whole-body and tissue carbohydrate and lipid metabolism, cardiovascular and renal function, and metabolic pathway kinetics. In addition to providing services, the MMPC staff provides expertise and advice to researchers, and works to develop and refine test protocols to best meet the community's needs in light of current scientific developments. Test technology is disseminated by publications and through annual courses.
小鼠代谢表型中心（MMPC）成立于 2001 年，由美国国立卫生研究院（NIH）创立，旨在通过为糖尿病、肥胖症及其并发症的小鼠模型提供标准化、高质量的表型服务，推动生物医学研究。其目的是让研究人员能够充分利用实验室和高通量公共努力中产生的许多新的小鼠模型。这 6 个 MMPC 分布在全国各地的大学，根据服务收费的方式，在完整的小鼠中进行复杂的代谢测试，并在组织中进行激素和分析物的检测。NIH 对测试进行补贴，以降低对小鼠研究人员的障碍。虽然这些测试的数据属于提交小鼠或组织的研究人员，但在 MMPC 协调和生物信息学部门运行的公共数据库中发表后，这些数据会被存档。人们希望使用标准协议在许多代谢疾病的小鼠模型中进行的实验数据，将有助于理解这些复杂疾病的性质。目前的专业领域包括能量平衡和身体成分、胰岛素作用和分泌、全身和组织碳水化合物和脂质代谢、心血管和肾功能以及代谢途径动力学。除了提供服务外，MMPC 工作人员还为研究人员提供专业知识和建议，并努力开发和完善测试方案，以根据当前科学发展，最好地满足社区的需求。测试技术通过出版物和年度课程进行传播。
