National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, USA.
Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, USA.
Mamm Genome. 2024 Dec;35(4):485-496. doi: 10.1007/s00335-024-10067-y. Epub 2024 Aug 27.
The Mouse Metabolic Phenotyping Center (MMPC)Live Program was established in 2023 by the National Institute for Diabetes, Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes and obesity. Emerging as the next iteration of the MMPC Program which served the biomedical research community for 20 years (2001-2021), MMPCLive is designed as an outwardly-facing consortium of service cores that collaborate to provide reduced-cost consultation and metabolic, physiologic, and behavioral phenotyping tests on live mice for U.S. biomedical researchers. Four MMPCLive Centers located at universities around the country perform complex and often unique procedures in vivo on a fee for service basis, typically on mice shipped from the client or directly from a repository or vendor. Current areas of expertise include energy balance and body composition, insulin action and secretion, whole body carbohydrate and lipid metabolism, cardiovascular and renal function, food intake and behavior, microbiome and xenometabolism, and metabolic pathway kinetics. Additionally, an opportunity arose to reduce barriers to access and expand the diversity of the biomedical research workforce by establishing the VIBRANT Program. Directed at researchers historically underrepresented in the biomedical sciences, VIBRANT-eligible investigators have access to testing services, travel and career development awards, expert advice and experimental design consultation, and short internships to learn test technologies. Data derived from experiments run by the Centers belongs to the researchers submitting mice for testing which can be made publicly available and accessible from the MMPCLive database following publication. In addition to services, MMPCLive staff provide expertise and advice to researchers, develop and refine test protocols, engage in outreach activities, publish scientific and technical papers, and conduct educational workshops and training sessions to aid researchers in unraveling the heterogeneity of diabetes and obesity.
小鼠代谢表型中心（MMPC）活体项目由美国国立卫生研究院（NIH）下属的美国国立糖尿病、消化和肾脏疾病研究所（NIDDK）于 2023 年成立，旨在通过为糖尿病和肥胖症小鼠模型提供标准化、高质量的表型服务，推进生物医学研究。作为 MMPC 计划的下一个迭代，该计划为生物医学研究界服务了 20 年（2001-2021 年），MMPCLive 旨在成为一个外向型服务核心联盟，合作提供活鼠的低成本咨询以及代谢、生理和行为表型测试，服务于美国生物医学研究人员。全国 4 个 MMPCLive 中心位于大学，按服务收费的方式，对活体小鼠进行复杂且通常是独特的体内程序，这些程序通常是在客户或直接从存储库或供应商那里运送的小鼠上进行的。目前的专业领域包括能量平衡和身体成分、胰岛素作用和分泌、全身碳水化合物和脂质代谢、心血管和肾功能、食物摄入和行为、微生物组和异种代谢以及代谢途径动力学。此外，通过建立 VIBRANT 计划，为减少获取障碍和扩大生物医学研究人员队伍的多样性提供了机会。VIBRANT 计划面向在生物医学科学领域代表性不足的研究人员，合格的研究人员可以获得测试服务、差旅和职业发展奖、专家建议和实验设计咨询以及短期实习机会，以学习测试技术。中心进行的实验所产生的数据属于提交小鼠进行测试的研究人员，这些数据可以在发表后从 MMPCLive 数据库公开获取。除了服务外，MMPCLive 工作人员还为研究人员提供专业知识和建议、开发和完善测试方案、开展外展活动、发表科学和技术论文，并举办教育研讨会和培训课程，帮助研究人员揭示糖尿病和肥胖症的异质性。
