James L C, Coohill T P
Mutat Res. 1979 Oct;62(3):407-15. doi: 10.1016/0027-5107(79)90036-8.
The combined effect of 8-methoxypsoralen (8-MOP) and ultraviolet (UV) radiation on the ability of an irradiated mammalian cell (CV-1) to reactivate UV-irradiated mammalian virus (Herpes simplex) was tested. Prior treatment of cells with 8-MOP was found to increase Radiation-Enhanced Reactivation (RER) at one wavelength (297 nm) in the far ultraviolet but not at others (240-289 nm). This same treatment induced RER in the near UV (302-370 nm) and the visible region (380-400 nm). An action spectrum for the photo-sensitized induction of this cellular parameter was obtained. This action spectrum is consistent with the absorption spectrum for 8-MOP and the theory that damage to DNA is, at least in part, responsible for Radiation-Enhanced Reactivation.
测试了8-甲氧基补骨脂素（8-MOP）与紫外线（UV）联合作用对受辐照哺乳动物细胞（CV-1）重新激活紫外线照射的哺乳动物病毒（单纯疱疹病毒）能力的影响。发现用8-MOP预先处理细胞可在远紫外线的一个波长（297nm）处增加辐射增强再激活（RER），但在其他波长（240 - 289nm）处则不然。相同处理在近紫外线（302 - 370nm）和可见光区域（380 - 400nm）诱导了RER。获得了该细胞参数光致敏诱导的作用光谱。该作用光谱与8-MOP的吸收光谱以及DNA损伤至少部分导致辐射增强再激活的理论一致。
