Nocentini S, Coppey J, Buisson J P, Royer R
Mutat Res. 1981 Oct;90(2):125-35. doi: 10.1016/0165-1218(81)90075-6.
Various 2-nitronaphthofuran derivatives (related to each other by simple structural modifications) were tested for 2 different effects in CV-1 monkey kidney cell cultures: the immediate inhibition of normal DNA synthesis and the capacity of pretreated cultures (40 h of contact) to support the replication of UV-damaged Herpes simplex virus (HSV). For all compounds tested, a fair correlation was found between their efficiencies to inhibit cellular DNA synthesis and to provoke an increase in UV-HSV production (virus reactivation). Virus reactivation was due to an increase in both the number of virus-producing cells and the amount of infectious particles produced per cell. The most efficient 2-nitronaphthofurans (particularly 2-nitro-7-methoxy-naphtho[2,1-b]furan-R 7000) were at least as potent as aflatoxin B1 in inducing virus reactivation.
对多种2-硝基萘并呋喃衍生物（通过简单的结构修饰相互关联）在CV-1猴肾细胞培养物中进行了两种不同效应的测试：对正常DNA合成的即时抑制作用，以及预处理培养物（接触40小时）支持紫外线损伤的单纯疱疹病毒（HSV）复制的能力。对于所有测试的化合物，发现它们抑制细胞DNA合成的效率与促使紫外线-HSV产生增加（病毒复活）之间存在合理的相关性。病毒复活是由于产生病毒的细胞数量增加以及每个细胞产生的感染性颗粒数量增加所致。最有效的2-硝基萘并呋喃（特别是2-硝基-7-甲氧基-萘并[2,1-b]呋喃-R 7000）在诱导病毒复活方面至少与黄曲霉毒素B1一样有效。
