Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Br J Ophthalmol. 2012 Nov;96(11):1410-4. doi: 10.1136/bjophthalmol-2012-301857. Epub 2012 Aug 31.
To evaluate the correlation of subretinal fluid height with visual acuity (VA) in patients with acute Vogt-Koyanagi-Harada disease (VKH).
Clinical information, fundus photographs and spectral domain optical coherence tomography scans from sequential visits of patients with acute VKH treated with oral corticosteroids were analysed. Subretinal fluid (SRF) height and retinal thickness were measured at the fovea. The association between VA and SRF height was evaluated by Spearman correlation analysis.
A total of 12 eyes from 6 consecutive patients were included. SRF height measured 824±508 µm (range 45-1900 µm) at presentation. SRF height correlated with simultaneously measured VA. Initial SRF height did not correlate with resolution time and final VA. Resolution of SRF was attained in 36±24 days (range 10-80 days). The presence of choroidal folds (eight eyes) and multifocal retinal detachment (eight eyes) at presentation correlated with lower initial VA but not with the interval to SRF resolution or with VA at 3-month follow-up.
Serous retinal detachment resolved in 36±24 days in patients with acute VKH treated with oral corticosteroids. SRF height correlates with VA measured at the same time. The initial SRF, no matter how elevated, does not correlate with VA at 3 months after presentation.
评估急性 Vogt-小柳-原田病（VKH）患者的视网膜下液高度与视力（VA）的相关性。
分析了接受口服皮质类固醇治疗的急性 VKH 患者的连续就诊的临床信息、眼底照片和频域光相干断层扫描。在黄斑处测量视网膜下液（SRF）高度和视网膜厚度。通过 Spearman 相关分析评估 VA 与 SRF 高度之间的关系。
共纳入 6 例连续患者的 12 只眼。在就诊时，SRF 高度为 824±508 µm（范围 45-1900 µm）。SRF 高度与同时测量的 VA 相关。初始 SRF 高度与恢复时间和最终 VA 无关。SRF 在 36±24 天（范围 10-80 天）内得到解决。就诊时存在脉络膜皱褶（8 只眼）和多灶性视网膜脱离（8 只眼）与初始 VA 较低相关，但与 SRF 恢复间隔或 3 个月随访时的 VA 无关。
接受口服皮质类固醇治疗的急性 VKH 患者的浆液性视网膜脱离在 36±24 天内得到解决。SRF 高度与同时测量的 VA 相关。初始 SRF 高度无论多高，与就诊后 3 个月的 VA 无关。
