在苏丹中部疟疾传播不稳定的地区，贫血妇女对胎盘疟疾的易感性降低。
Decreased susceptibility to placental malaria in anaemic women in an area with unstable malaria transmission in central Sudan.
机构信息
University of Khartoum, Khartoum, Sudan.
出版信息
Pathog Glob Health. 2012 May;106(2):118-21. doi: 10.1179/2047773212Y.0000000011.
The interaction between iron level, iron supplementation, and susceptibility to infection, including malaria, remains a concern. A cross-sectional study was conducted at Medani hospital in central Sudan to investigate the relationship between anaemia and placental malaria. Obstetrical history was obtained; haemoglobin levels were determined. Placental tissue was obtained and malaria histology classified as active, chronic, past or no malaria infection. Among 324 women investigated, 7 (2·2%), 4 (1·2%), and 44 (13·6%) of the placentae showed active, chronic and past infection on histology examination respectively, while 269 (83·0%) of them showed no infection. Anaemia (haemoglobin <11 g/dl) was less frequent in women with placental Plasmodium falciparum infection, 27/55 (49·1%) vs 174/269 (64·7%), P=0·02. Anaemia was associated with a decreased risk for placental malaria, and the odds ratio for placental malaria (in both primiparae and multiparae group) was 0·2, 95% CI: 0·1-0·6, P=0·002 and it was 0·2, 95% CI: 0·03-0·7; P=0·02 for primiparae group. Thus, there is a strong relationship between anaemia and the absence of placental malaria.
铁水平、铁补充剂和感染易感性（包括疟疾）之间的相互作用仍然令人关注。在苏丹中部的 Medani 医院进行了一项横断面研究，以调查贫血与胎盘疟疾之间的关系。获得了产科病史；测定了血红蛋白水平。获得胎盘组织，并对疟疾组织学进行分类为活动、慢性、既往或无疟疾感染。在调查的 324 名妇女中，7 名（2.2%）、4 名（1.2%）和 44 名（13.6%）的胎盘组织在组织学检查中分别显示出活动、慢性和既往感染，而 269 名（83.0%）的胎盘组织没有感染。贫血（血红蛋白<11g/dl）在胎盘疟原虫感染的妇女中较少见，55 名妇女中有 27 名（49.1%）与 269 名妇女中有 174 名（64.7%）相比，P=0.02。贫血与胎盘疟疾的风险降低相关，胎盘疟疾的比值比（在初产妇和经产妇组中）为 0.2，95%CI：0.1-0.6，P=0.002，比值比为 0.2，95%CI：0.03-0.7；P=0.02，初产妇组。因此，贫血与无胎盘疟疾之间存在很强的关系。
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