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负压辅助脉冲冲洗:与传统敷料比较治疗慢性伤口愈合的随机对照研究。

Suction assisted pulse lavage: randomised controlled studies comparing its efficacy with conventional dressings in healing of chronic wounds.

机构信息

Department of Plastic and Reconstructive Surgery, Christian Medical College, Vellore, Tamil Nadu, India.

出版信息

Int Wound J. 2014 Feb;11(1):55-63. doi: 10.1111/j.1742-481X.2012.01062.x. Epub 2012 Sep 3.

Abstract

Chronic, open, non-healing wounds pose a continual challenge in medicine as the treatment is variable and there are no documented consistent responses. Although wound aetiologies vary and there are a number of factors that affect chronic wound pathogenesis, wound ischaemia and bacterial colonisation of wounds are the chief concerns among them. Conventionally, pulse lavage has been used primarily as a wound debriding device. To address both the critical factors of wound ischaemia and bacterial burden, a couple of technical points were proposed and applied in this study. The objective of our study was to evaluate pulse lavage therapy's ability to improve the healing rate of chronic wounds compared to that of the traditional saline-wet-to-moist dressings. The study period was from 1 August 2010 to 31 January 2012 and was conducted in our institution. Thirty patients with 31 chronic, non-healing wounds were enrolled in the study after obtaining proper consent. Subjects were randomised (15 patients each) to the pulse lavage group and the control group. Patients in the test group were subjected to irrigation of their wounds with pulsed lavage at 10 to 15 psi pressure. In the control group, wound was closed by applying moist betadine saline gauze dressings after cleaning with saline. Wounds treated with pulse lavage system significantly reduced in size, had better control of bacterial contamination and had overall faster healing rates. Efficacy of pulse lavage can be increased by correct method of administration of the irrigant.

摘要

慢性、开放性、不愈合的伤口在医学上一直是一个挑战,因为治疗方法各不相同,而且没有记录到一致的治疗反应。尽管伤口病因不同,有许多因素影响慢性伤口的发病机制,但伤口缺血和细菌定植是其中的主要关注点。传统上,脉冲灌洗主要用作清创设备。为了解决伤口缺血和细菌负担这两个关键因素,本研究提出并应用了一些技术要点。我们的研究目的是评估脉冲灌洗疗法与传统的盐水湿到湿敷料相比,提高慢性伤口愈合率的能力。研究时间为 2010 年 8 月 1 日至 2012 年 1 月 31 日,在我们的机构进行。在获得适当同意后,30 名患有 31 处慢性不愈合伤口的患者被纳入本研究。受试者被随机(每组 15 名)分为脉冲灌洗组和对照组。试验组患者的伤口用 10 到 15 磅/平方英寸的脉冲灌洗进行冲洗。在对照组中,用生理盐水清洗后,用湿润的贝他碘盐水纱布敷料封闭伤口。用脉冲灌洗系统治疗的伤口明显缩小,细菌污染得到更好的控制,整体愈合速度更快。通过正确的冲洗剂给药方法,可以提高脉冲灌洗的疗效。

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