Tozzi Alberto E, Mazzotti Eva, Di Ciommo Vincenzo Maria, Dello Strologo Luca, Cuttini Marina
Epidemiology Unit, Bambino Gesù Hospital, Rome, Italy.
Pediatr Transplant. 2012 Dec;16(8):840-5. doi: 10.1111/j.1399-3046.2012.01774.x. Epub 2012 Sep 4.
Studies on HRQOL on kidney-transplanted young adults who had a diagnosis of chronic renal failure (CRF) in the pediatric age are uncommon. We studied HRQOL and its predictors in a sample of young adults with CRF in childhood who underwent a renal transplant. We recruited patients ≥18 yr old with renal transplant. We measured HRQOL by a standardized questionnaire on lifestyle, Short Form-36 (SF-36; including a PCS and a MCS; scale: 0-100), the GHQ (for short-term changes in mental health; scale: 0-36), and the MSPSS (with scales for family, friends, and significant others; scale: 0-100). We assessed the association of potential predictors of HRQOL through multiple linear regression models. We studied 66 patients aged 18-34 yr. The average PCS score was 76.4, and the average MCS score was 73.9. The mean GHQ total score was 14.8, and the total scale MSPSS mean score was 70. Severe comorbidities significantly affected the PCS score. Individuals with severe comorbidities had lower PCS scores.
针对儿童期被诊断为慢性肾衰竭（CRF）的肾移植青年成人的健康相关生活质量（HRQOL）研究并不常见。我们对一组童年期患有CRF且接受了肾移植的青年成人样本的HRQOL及其预测因素进行了研究。我们招募了年龄≥18岁的肾移植患者。我们通过一份关于生活方式的标准化问卷、简短健康调查问卷-36（SF-36；包括一个生理健康综合评分和一个心理健康综合评分；范围：0-100）、一般健康问卷（GHQ，用于评估心理健康的短期变化；范围：0-36）以及多维社会支持感知量表（MSPSS，有针对家庭、朋友和重要他人的量表；范围：0-100）来测量HRQOL。我们通过多元线性回归模型评估HRQOL潜在预测因素之间的关联。我们研究了66名年龄在18至34岁之间的患者。生理健康综合评分的平均值为76.4，心理健康综合评分的平均值为73.9。GHQ总分的平均值为14.8，MSPSS量表总分的平均值为70。严重的合并症显著影响生理健康综合评分。患有严重合并症的个体生理健康综合评分较低。
