Chkhotua A, Pantsulaia T, Managadze L
National Centre of Urology, Tbilisi, Georgia.
Georgian Med News. 2011 Nov;11(200):10-7.
Health-related quality of life (HRQoL) is becoming an important outcome measure in evaluation of various forms of renal replacement therapy (RRT). The Short Form-36 (SF-36), Giessen Subjective Complaints List (GBB-24) and Zerssen's Mood-Scale (Bf-S) are internationally validated questionnaires for the assessment of HRQoL. The goal of the current study was to evaluate and compare the HRQoL of patients on different forms of the RRT. The study population consisted of: 1) 120 patients on hemodialysis (HD); 2) 43 patients on peritoneal dialysis (PD); 3) 9 recipients who lost their grafts and went back to dialysis (PT); 4) 120 age- and sex matched healthy individuals (Controls); and 5) 48 renal transplant recipients (T). The SF-36, GBB-24 and Bf-S questionnaires have been used for the assessment of HRQoL. The mean SF-36 scores were not significantly different between: a) control group and transplant recipients; b) hemo- and peritoneal dialysis patients including previously transplanted patients. The dialysis patients scored significantly worse in all eight SF-36 domains as compared with the transplant recipients and healthy subjects. In all GBB-24 components the transplant recipients scored significantly higher than HD and PD patients. In the following components: "Fatigue tendency", "Limb pain" and "Cardiac complaints", recipients scored significantly higher than the control group subjects. The mood analysis (Bf-S) has shown that the scores of transplant recipients and controls did not differ and were significantly higher than that of the dialysis patients. The HRQoL of patients on hemo- and peritoneal dialysis is similar and lower than that of the general population. Renal transplantation significantly improves HRQoL at least to the level of the healthy individuals. The graft loss is associated with the significant worsening of HRQoL.
健康相关生活质量（HRQoL）正成为评估各种形式肾脏替代治疗（RRT）的一项重要结果指标。简明健康状况调查问卷（SF-36）、吉森主观症状清单（GBB-24）和泽尔森情绪量表（Bf-S）是国际上经过验证的用于评估健康相关生活质量的问卷。本研究的目的是评估和比较接受不同形式肾脏替代治疗患者的健康相关生活质量。研究人群包括：1）120例血液透析（HD）患者；2）43例腹膜透析（PD）患者；3）9例移植肾失功并重新接受透析的患者（PT）；4）120例年龄和性别匹配的健康个体（对照组）；5）48例肾移植受者（T）。采用SF-36、GBB-24和Bf-S问卷评估健康相关生活质量。SF-36平均得分在以下两组之间无显著差异：a）对照组与移植受者；b）血液透析和腹膜透析患者，包括既往接受过移植的患者。与移植受者和健康受试者相比，透析患者在SF-36的所有八个领域得分均显著更低。在GBB-24的所有项目中，移植受者得分显著高于血液透析和腹膜透析患者。在以下项目中： “疲劳倾向 ”、“肢体疼痛 ”和 “心脏不适”，移植受者得分显著高于对照组受试者。情绪分析（Bf-S）显示，移植受者和对照组的得分无差异，且显著高于透析患者。血液透析和腹膜透析患者的健康相关生活质量相似且低于普通人群。肾移植可显著改善健康相关生活质量，至少提高到健康个体的水平。移植肾失功与健康相关生活质量的显著恶化有关。
