儿童逆境与精神病：采用同卵双胞胎差异法检验关联是否归因于遗传混杂。
Childhood adversity and psychosis: examining whether the association is due to genetic confounding using a monozygotic twin differences approach.
机构信息
Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona, Avenue Diagonal 643, 08028 Barcelona, Spain.
出版信息
Eur Psychiatry. 2013 May;28(4):207-12. doi: 10.1016/j.eurpsy.2012.03.001. Epub 2012 Sep 1.
PURPOSE
To test whether the association between childhood adversity and positive and negative psychotic experiences is due to genetic confounding.
METHOD
Childhood adversity and psychotic experiences were assessed in an ongoing sample of 226 twins from the general population. A monozygotic (MZ) twin differences approach was used to assess possible genetic confounding.
RESULTS
In the whole sample, childhood adversity was significantly associated with positive (β=45; SE=0.16; P=0.008) and negative psychotic experiences (β=0.77; SE=0.18; P<0.01). Within-pair MZ twin differences in exposure to childhood adversity were significantly associated with differences in positive (β=71; SE=0.29; P=0.016) and negative psychotic experiences (β=98; SE=0.38; P=0.014) in a subsample of 85 MZ twin pairs.
CONCLUSIONS
Individuals exposed to childhood adversity are more likely to report psychotic experiences. Furthermore, our findings indicate that this association is not due to genetic confounding.
目的
检验童年逆境与正性和负性精神病体验之间的关联是否归因于遗传混杂。
方法
在一个来自普通人群的 226 对双胞胎的进行中的样本中评估了童年逆境和精神病体验。采用同卵（MZ）双胞胎差异法来评估可能的遗传混杂。
结果
在整个样本中，童年逆境与正性精神病体验（β=45；SE=0.16；P=0.008）和负性精神病体验（β=0.77；SE=0.18；P<0.01）显著相关。在 85 对 MZ 双胞胎样本中，暴露于童年逆境的同卵双胞胎之间的差异与正性精神病体验（β=71；SE=0.29；P=0.016）和负性精神病体验（β=98；SE=0.38；P=0.014）的差异显著相关。
结论
暴露于童年逆境的个体更有可能报告精神病体验。此外，我们的研究结果表明，这种关联不是由于遗传混杂造成的。
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