乌鲁克他丁A，一种源自海洋的无孢麦氏菌YM11 - 542产生的新型细胞毒性物质。I. 发酵、分离及生物活性。
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities.
作者信息
Matsuo Yoshihide, Kanoh Kaneo, Yamori Takao, Kasai Hiroaki, Katsuta Atsuko, Adachi Kyoko, Shin-Ya Kazuo, Shizuri Yoshikazu
机构信息
Marine Biotechnology Institute Co. Ltd., Heita, Kamaishi, Iwate.
出版信息
J Antibiot (Tokyo). 2007 Apr;60(4):251-5. doi: 10.1038/ja.2007.30.
Urukthapelstatin A, a novel cyclic peptide, was isolated from the cultured mycelia of marine-derived Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The peptide was purified by solvent extraction, silica gel chromatography, ODS flash chromatography, and finally by preparative HPLC. Urukthapelstatin A dose-dependently inhibited the growth of human lung cancer A549 cells with an IC(50) value of 12 nM. Urukthapelstatin A also showed potent cytotoxic activity against a human cancer cell line panel.
乌鲁克他司他汀A是一种新型环肽，从海洋来源的嗜热放线菌科细菌无孢子产丝菌YM11 - 542的培养菌丝体中分离得到。该肽通过溶剂萃取、硅胶柱色谱、ODS快速柱色谱，最后通过制备型高效液相色谱进行纯化。乌鲁克他司他汀A对人肺癌A549细胞的生长具有剂量依赖性抑制作用，IC(50)值为12 nM。乌鲁克他司他汀A对一组人癌细胞系也显示出强大的细胞毒活性。
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