Microscopy Core Facility, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
J Cell Biol. 2012 Sep 3;198(5):773-83. doi: 10.1083/jcb.201203170.
Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed "NETosis." Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.
中性粒细胞胞外诱捕网（NETs）由处理后的染色质与颗粒和选定的细胞质蛋白结合而成。NETs 由称为中性粒细胞的白细胞释放，可能是作为控制微生物感染的最后手段。这种染色质的释放是一种独特的细胞死亡形式，称为“NETosis”。在这里，我们回顾了我们对 NETs 如何形成、它们在感染和作为危险信号中的功能以及它们在自身免疫和凝血中的新出现的重要性的理解。
