Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Eur J Clin Invest. 2012 Nov;42(11):1221-6. doi: 10.1111/j.1365-2362.2012.02714.x. Epub 2012 Sep 4.
The hallmark of vascular inflammation is the recruitment of circulating leucocytes, primarily monocytes, macrophages and T lymphocytes, into the vascular wall; however, the link between monocyte/macrophage activation and hypertension has not been established as yet. In this study, we determined how sCD163, a monocyte/macrophage soluble scavenger receptor and immunomodulator, relates to arterial blood pressure (BP) in hypertensive Saudi individuals.
A total of 90 (30 non-hypertensive obese, 30 hypertensive obese and 30 lean normotensive controls) adult Saudi subjects, aged 40-60 years, participated in this cross-sectional study. Serum fasting blood glucose, triglycerides, total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), leptin, adiponectin, resistin, insulin, tumour necrosis factor-alpha (TNF-α), PAI-1, angiotensin II, high-sensitivity C-reactive protein (hsCRP) and sCD163 were measured in all subjects studied.
sCD163 concentrations were significantly increased in obese hypertensive patients compared to controls (P=0.016). Positive correlations between sCD163 and body mass index (BMI) (r=0.27, P=0.01), systolic BP (r=0.25, P=0.01), diastolic BP (r=0.33, P=0.001), LDL-C (r=0.21, P=0.04), TNF-α (r=0.23, P=0.02) and hsCRP (r=0.33, P=0.008) were observed. Positive correlations between sCD163 and diastolic BP (r=0.23, P=0.04) and LDL-C (r=0.22, P=0.03) remained significant after controlling for BMI.
Taken together, these data demonstrate that the monocyte/macrophage activation-related sCD163 is positively associated with BMI and increased arterial BP with the elevation in diastolic BP being independent of the BMI.
血管炎症的标志是循环白细胞（主要是单核细胞、巨噬细胞和 T 淋巴细胞）募集到血管壁中；然而，单核细胞/巨噬细胞活化与高血压之间的联系尚未确定。在这项研究中，我们确定了单核细胞/巨噬细胞可溶性清道夫受体和免疫调节剂 sCD163 与沙特高血压个体的动脉血压（BP）之间的关系。
共有 90 名（30 名非肥胖高血压患者、30 名肥胖高血压患者和 30 名正常体重非高血压对照组）年龄在 40-60 岁的成年沙特受试者参加了这项横断面研究。所有研究对象均测量空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、瘦素、脂联素、抵抗素、胰岛素、肿瘤坏死因子-α（TNF-α）、纤溶酶原激活物抑制剂-1（PAI-1）、血管紧张素 II、高敏 C 反应蛋白（hsCRP）和 sCD163。
肥胖高血压患者的 sCD163 浓度明显高于对照组（P=0.016）。sCD163 与体重指数（BMI）（r=0.27，P=0.01）、收缩压（r=0.25，P=0.01）、舒张压（r=0.33，P=0.001）、LDL-C（r=0.21，P=0.04）、TNF-α（r=0.23，P=0.02）和 hsCRP（r=0.33，P=0.008）呈正相关。控制 BMI 后，sCD163 与舒张压（r=0.23，P=0.04）和 LDL-C（r=0.22，P=0.03）的相关性仍有统计学意义。
综上所述，这些数据表明，与单核细胞/巨噬细胞活化相关的 sCD163 与 BMI 呈正相关，与动脉血压升高相关，其中舒张压升高与 BMI 无关。
