Bayliss K M, Kueck B D, Hanson C A, Matthaeus W G, Almagro U A
Department of Pathology, Medical College of Wisconsin, Milwaukee.
Am J Clin Pathol. 1990 Jan;93(1):117-23. doi: 10.1093/ajcp/93.1.117.
The development of a central nervous system (CNS) large cell lymphoma in a patient simultaneously diagnosed with chronic lymphocytic leukemia (CLL) is reported. Although differences in phenotypic expression were demonstrated in study of the peripheral blood and CNS disease, identical immunoglobulin gene rearrangements were identified, providing evidence for evolution of two morphologically distinct neoplasms from the same clone. Beyond histologic transformation, acquisition of an aneuploid cell population in the CNS tumor was demonstrated by analysis of DNA content. Isolated parenchymal involvement of the CNS by large cell transformation of CLL has not been previously described; its relationship to CNS lymphoma and Richter's syndrome are reviewed.
报告了1例同时诊断为慢性淋巴细胞白血病（CLL）的患者发生中枢神经系统（CNS）大细胞淋巴瘤的情况。尽管在外周血和CNS疾病的研究中显示出表型表达存在差异，但却鉴定出相同的免疫球蛋白基因重排，这为两种形态学上不同的肿瘤源自同一克隆的演变提供了证据。除了组织学转化外，通过DNA含量分析证实CNS肿瘤中存在非整倍体细胞群。CLL大细胞转化导致的CNS孤立性实质受累此前未见报道；本文对其与CNS淋巴瘤及 Richter 综合征的关系进行了综述。
