Eash S, Manley K, Gasparovic M, Querbes W, Atwood W J
Graduate Program in Pathobiology, Brown University, Providence, Rhode Island, 02912, USA.
Cell Mol Life Sci. 2006 Apr;63(7-8):865-76. doi: 10.1007/s00018-005-5454-z.
The Polyomavirus family includes two members, BK virus (BKV) and JC virus (JCV), that naturally infect humans. These viruses are widely distributed among the population worldwide. Primary infection occurs in early childhood and remains for life clinically unapparent in immunocompetent individuals. In the context of severe immunosuppression and other predisposing factors BKV and JCV may reactivate and cause serious illnesses known as Polyomavirus-induced nephropathy and progressive multifocal leukoencephalopathy, respectively. Here we briefly examine the biological and physical characteristics and the lifecycle, namely receptor(s) interaction, mode of entry, intracellular trafficking, viral transcription and replication, and progeny assembly of these two human Polyomaviruses. We also provide an overview of the clinical manifestation of Polyomavirus-induced disorders in affected individuals and discuss the potential involvement of BKV and JCV in human cancer.
多瘤病毒科包括BK病毒（BKV）和JC病毒（JCV）这两个自然感染人类的成员。这些病毒在全球人群中广泛分布。初次感染发生在儿童早期，在免疫功能正常的个体中临床上终生不明显。在严重免疫抑制和其他易感因素的情况下，BKV和JCV可能重新激活，并分别导致称为多瘤病毒诱导的肾病和进行性多灶性白质脑病的严重疾病。在这里，我们简要研究这两种人类多瘤病毒的生物学和物理特性以及生命周期，即受体相互作用、进入方式、细胞内运输、病毒转录和复制以及子代组装。我们还概述了受影响个体中多瘤病毒诱导的疾病的临床表现，并讨论了BKV和JCV在人类癌症中的潜在作用。
