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克罗恩病回肠末端切除术后联合加速康复路径行腹腔镜治疗的短期疗效:病例对照分析。

Short-term outcomes of laparoscopy combined with enhanced recovery pathway after ileocecal resection for Crohn's disease: a case-matched analysis.

机构信息

Department and Chair of General Surgery, Istituto Clinico Humanitas-IRCCS, University of Milan, Via Alessandro Manzoni 56, 20089, Rozzano, Milan, Italy.

出版信息

J Gastrointest Surg. 2013 Jan;17(1):126-32; discussion p.132. doi: 10.1007/s11605-012-2012-5. Epub 2012 Sep 5.

Abstract

BACKGROUND

Laparoscopy combined with an enhanced recovery pathway (ERP) is widely considered to be the first-choice option for patients with colorectal cancer. However, no previous reports have focused on patients with Crohn's disease (CD) treated by laparoscopy and ERP.

METHODS

Twenty patients with CD underwent laparoscopic ileocecal resection with an ERP at two institutions. The ERP protocol included no bowel preparation nor fasting, no nasogastric tube, no abdominal drains, early removal of urinary catheter, early solid dietary intake and mobilization, opioid-sparing analgesia and restrictive fluid management. This group was compared with a matched historical control group of 70 CD patients who underwent laparoscopic ileocecal resection treated with conventional care.

RESULTS

Compliance with the ERP was high (≥80 %) for all items except no drain placement. A significantly earlier return of bowel function (time to first flatus and stool) was observed in the ERP group. Mean postoperative and total length of stay were significantly shorter in the ERP group. Postoperative complications were similar in both groups.

CONCLUSIONS

This is the first reported experience of laparoscopy with ERP in CD patients and suggests that optimized perioperative care combined with minimally invasive techniques may lead to further improvements in surgical outcomes for CD patients.

摘要

背景

腹腔镜联合加速康复路径(ERP)被广泛认为是结直肠癌患者的首选治疗方案。然而,目前尚无针对接受腹腔镜和 ERP 治疗的克罗恩病(CD)患者的相关报道。

方法

本研究回顾性分析了在两家机构接受腹腔镜回盲部切除术联合 ERP 治疗的 20 例 CD 患者的临床资料。ERP 方案包括不进行肠道准备和禁食、不放置鼻胃管、不留置腹腔引流管、尽早拔除导尿管、早期恢复固体饮食和活动、使用阿片类药物联合非甾体类抗炎药镇痛以及限制液体管理。将该组患者与接受传统治疗的 70 例接受腹腔镜回盲部切除术的 CD 患者的匹配历史对照组进行比较。

结果

除未放置引流管外,所有项目的 ERP 依从性均较高(≥80%)。ERP 组患者术后首次排气和排便时间更早,术后和总住院时间更短。两组患者的术后并发症发生率相似。

结论

这是首例关于 CD 患者腹腔镜联合 ERP 的报道,提示优化围手术期管理联合微创手术可能会进一步改善 CD 患者的手术结局。

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