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喹诺酮类抗生素：耐药性与治疗

Quinolone Antibiotics: Resistance and Therapy.

作者信息

Tang Kai, Zhao Heng

机构信息

Fujian Provincial Key Laboratory of Innate Immune Biology, Fujian Normal University, Fujian, People's Republic of China.

出版信息

Infect Drug Resist. 2023 Feb 10;16:811-820. doi: 10.2147/IDR.S401663. eCollection 2023.

DOI:10.2147/IDR.S401663
PMID:36798480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9926991/
Abstract

The clinical application of quinolone antibiotics is particularly extensive. In addition to their high efficiency in infectious diseases, the treatment process brings multiple hidden dangers or side effects. In this regard, drug resistance becomes a major challenge and is almost unavoidable in the clinical application of quinolones. Both genetic and phenotypic variations contribute to bacterial survival resistance under antibiotic therapy. This review is focusing on the drug discovery history, compound structure, and bactericidal mechanism of quinolone antibiotics. Recent studies bring a more in-depth insight into the research progress of quinolone antibiotics in the causes of death, drug resistance formation, and closely related SOS response after disease treatment at this stage. Combined with the latest clinical studies, we summarize the clinical application of quinolone antibiotics and further lay a theoretical foundation for the mechanism study of resistant or sensitive bacteria in response to quinolone treatment.

摘要

喹诺酮类抗生素的临床应用尤为广泛。除了在传染病治疗中具有高效性外，其治疗过程也带来了多种隐患或副作用。在这方面，耐药性成为一个重大挑战，并且在喹诺酮类药物的临床应用中几乎难以避免。遗传和表型变异均有助于细菌在抗生素治疗下产生生存抗性。本综述聚焦于喹诺酮类抗生素的药物发现史、化合物结构及杀菌机制。近期的研究更深入地洞察了现阶段喹诺酮类抗生素在疾病治疗后的死亡原因、耐药性形成以及与之密切相关的SOS反应等方面的研究进展。结合最新的临床研究，我们总结了喹诺酮类抗生素的临床应用，并进一步为耐药或敏感细菌对喹诺酮治疗反应的机制研究奠定理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/9926991/e73d1e255321/IDR-16-811-g0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/9926991/af14b76a1ff4/IDR-16-811-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/9926991/206703a0cfd0/IDR-16-811-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/9926991/6548206084b0/IDR-16-811-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/9926991/8bf091435468/IDR-16-811-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/9926991/e73d1e255321/IDR-16-811-g0005.jpg

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