Sanquin Research, Department of Donor Studies, Geert Grooteplein Zuid 34, PO Box 1013, 6501BA Nijmegen, the Netherlands.
Hypertension. 2012 Oct;60(4):936-41. doi: 10.1161/HYPERTENSIONAHA.112.193565. Epub 2012 Sep 4.
It has been hypothesized that an increased hemoglobin level elevates blood pressure. The present study investigated the association between hemoglobin level and systolic blood pressure and diastolic blood pressure in healthy persons. The study population was composed of 101 377 whole blood and plasma donors, who made 691 107 visits to the blood bank. At each visit, hemoglobin level and blood pressure were measured as part of the standard procedure before a blood donation. We used repeated measurement analysis to analyze the data. We used generalized estimating equation models to assess the between-person effect and linear mixed models to assess the within-person effect. All of the analyses were done separately for men and women. In the study population, 50% were men. The mean age in men was 49.3 years (±12.5 years), and in women it was 42.4 years (±13.7 years). Hemoglobin level was positively associated with both systolic and diastolic blood pressures. With respect to the between-person effect, regression coefficients for systolic blood pressure were 1.3 mm Hg per millimole per liter increase in hemoglobin level for men and 1.8 mm Hg per millimole per liter increase in hemoglobin level for women. With respect to the within-person effect, regression coefficients for systolic blood pressure were 0.7 mm Hg and 0.9 mm Hg per millimole per liter increase in hemoglobin level, for men and women, respectively. For diastolic blood pressure, results were comparable. The results show that hemoglobin level is positively associated with both systolic and diastolic blood pressures in healthy individuals. We observed consistent effects between persons but also within persons.
有人假设血红蛋白水平升高会导致血压升高。本研究调查了健康人群中血红蛋白水平与收缩压和舒张压之间的关系。研究人群由 101377 名全血和血浆供体组成，他们共到血库就诊 691107 次。每次就诊时，在献血前的标准程序中测量血红蛋白水平和血压。我们使用重复测量分析来分析数据。我们使用广义估计方程模型评估个体间效应，使用线性混合模型评估个体内效应。所有分析均分别在男性和女性中进行。在研究人群中，有 50%是男性。男性的平均年龄为 49.3 岁（±12.5 岁），女性为 42.4 岁（±13.7 岁）。血红蛋白水平与收缩压和舒张压均呈正相关。就个体间效应而言，血红蛋白水平每增加 1 毫摩尔/升，男性收缩压的回归系数为 1.3 毫米汞柱，女性为 1.8 毫米汞柱。就个体内效应而言，血红蛋白水平每增加 1 毫摩尔/升，男性和女性的收缩压回归系数分别为 0.7 毫米汞柱和 0.9 毫米汞柱。对于舒张压，结果相似。结果表明，血红蛋白水平与健康个体的收缩压和舒张压均呈正相关。我们观察到个体间存在一致的影响，也存在个体内的影响。
