由卡马西平和阿米替林联用引起的抗精神病药恶性综合征。
Neuroleptic malignant syndrome caused by a combination of carbamazepine and amitriptyline.
作者信息
Janati A Bruce, Alghasab Naif, Osman Aboubaker
机构信息
Center For Neurology, Fairfax, VA 22031, USA.
出版信息
Case Rep Neurol Med. 2012;2012:183252. doi: 10.1155/2012/183252. Epub 2012 Jul 24.
Abstract
A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. The purpose of this paper is to warn physicians against combination therapy with carbamazepine and tricyclic antidepressants which may be conducive to neuroleptic malignant syndrome in susceptible patients.
摘要
一名32岁女性，有继发性全身性惊厥性癫痫、智力发育迟缓及精神疾病史，在同时服用卡马西平和阿米替林时发生了抗精神病药恶性综合征。我们推测，在卡马西平基础上加用阿米替林导致卡马西平血清水平降低，从而引发了抗精神病药恶性综合征。我们得出结论，对于易发生抗精神病药恶性综合征的患者，应避免卡马西平和阿米替林联合治疗。本文旨在提醒医生，卡马西平和三环类抗抑郁药联合治疗可能会使易感患者发生抗精神病药恶性综合征。
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Case Rep Neurol Med. 2012;2012:183252. doi: 10.1155/2012/183252. Epub 2012 Jul 24.
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本文引用的文献
1
[A non-phenothiazine and non-reserpine major neuroleptic, haloperidol, in the treatment of psychoses].[一种非吩噻嗪类和非利血平类的主要抗精神病药物，氟哌啶醇，用于治疗精神病]
Ann Med Psychol (Paris). 1960 Jan;118(1):145-52.
2
The neuroleptic malignant and serotonin syndromes.抗精神病药恶性综合征和血清素综合征。
Emerg Med Clin North Am. 2000 May;18(2):317-25, x. doi: 10.1016/s0733-8627(05)70127-9.
3
Lack of association between neuroleptic malignant syndrome and polymorphisms in the 5-HT1A and 5-HT2A receptor genes.抗精神病药恶性综合征与5-HT1A和5-HT2A受体基因多态性之间无关联。
Am J Psychiatry. 1998 Sep;155(9):1275-7. doi: 10.1176/ajp.155.9.1275.
4
Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes.三环抗抑郁药阿米替林经cDNA表达的人细胞色素P450酶的代谢
Pharmacology. 1997 Nov;55(5):235-43. doi: 10.1159/000139533.
5
Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B.抗精神病药恶性综合征与羟化酶基因突变：与CYP2D6A或CYP2D6B无关联。
Psychiatr Genet. 1997 Autumn;7(3):127-9. doi: 10.1097/00041444-199723000-00007.
6
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.人肝脏中卡马西平的代谢。CYP3A4和CYP2C8在10,11-环氧化物形成中的作用。
Biochem Pharmacol. 1994 Jun 1;47(11):1969-79. doi: 10.1016/0006-2952(94)90071-x.
7
Successful treatment of neuroleptic malignant syndrome with bromocriptine.用溴隐亭成功治疗神经阻滞剂恶性综合征。
South Med J. 1986 Dec;79(12):1567-71. doi: 10.1097/00007611-198612000-00022.
8
Neuroleptic malignant syndrome.抗精神病药恶性综合征
Psychopharmacol Bull. 1988;24(1):25-9.
9
Effects of carbamazepine on serum antidepressant concentrations in psychiatric patients.卡马西平对精神科患者血清抗抑郁药浓度的影响。
J Clin Psychopharmacol. 1991 Oct;11(5):313-8.
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