Bracken M B, Hellenbrand K G, Holford T R
Yale University, New Haven, Connecticut.
Fertil Steril. 1990 Jan;53(1):21-7.
A significant delay was observed in conception among 248 former oral contraceptive (OC) users compared with women discontinuing other methods of contraception (n = 1,365). The mean time to conception was 5.88 cycles (95% confidence interval [CI] 5.38, 6.38) for former OC users and 3.64 cycles (95% CI 3.49, 3.79) after other contraceptives. Women discontinuing OCs with higher doses of estrogen (greater than or equal to 50 micrograms) had greater conception delays than those on lower estrogen doses who, in turn, had longer delays than other method users. Oral contraceptive use was associated with significant reductions in conception for each of the first six cycles after discontinuation. This study provides further evidence for a direct effect of oral contraception on delayed conception, suggests that the delay lasts longer than previously thought, and finds that the probability of conception after OC discontinuation depends on the estrogen dose of the OC.
与停用其他避孕方法的女性（n = 1365）相比，248名 former oral contraceptive (OC) users 在受孕方面出现了显著延迟。former OC users 的平均受孕时间为5.88个周期（95%置信区间[CI] 5.38, 6.38），而停用其他避孕方法后的女性平均受孕时间为3.64个周期（95% CI 3.49, 3.79）。停用雌激素剂量较高（大于或等于50微克）的OC的女性受孕延迟时间比使用低雌激素剂量的女性更长，而后者又比使用其他避孕方法的女性延迟时间更长。停用OC后的前六个周期中，每个周期的受孕率都因使用口服避孕药而显著降低。本研究为口服避孕药对受孕延迟的直接影响提供了进一步证据，表明延迟持续时间比以前认为的更长，并发现停用OC后受孕的概率取决于OC的雌激素剂量。
