Merrill A H, Hoel M, Wang E, Mullins R E, Hargrove J L, Jones D P, Popova I A
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.
FASEB J. 1990 Jan;4(1):95-100. doi: 10.1096/fasebj.4.1.2295381.
To determine the possible biochemical effects of prolonged weightlessness on liver function, samples of liver from rats that had flown aboard Cosmos 1887 were analyzed for protein, glycogen, and lipids as well as the activities of a number of key enzymes involved in metabolism of these compounds and xenobiotics. Among the parameters measured, the major differences were elevations in the glycogen content and hydroxymethylglutaryl-CoA (HMG-CoA) reductase activities for the rats flown on Cosmos 1887 and decreases in the amount of microsomal cytochrome P-450 and the activities of aniline hydroxylase and ethylmorphine N-demethylase, cytochrome P-450-dependent enzymes. These results support the earlier finding of differences in these parameters and suggest that altered hepatic function could be important during spaceflight and/or the postflight recovery period.
为了确定长期失重对肝功能可能产生的生化影响，对搭乘“宇宙1887号”飞行的大鼠的肝脏样本进行了分析，检测了蛋白质、糖原、脂质以及参与这些化合物和外源性物质代谢的一些关键酶的活性。在所测量的参数中，主要差异在于搭乘“宇宙1887号”飞行的大鼠糖原含量和羟甲基戊二酰辅酶A（HMG-CoA）还原酶活性升高，而微粒体细胞色素P-450的量以及苯胺羟化酶和乙基吗啡N-脱甲基酶（细胞色素P-450依赖性酶）的活性降低。这些结果支持了早期关于这些参数差异的发现，并表明肝功能改变在太空飞行期间和/或飞行后恢复期可能很重要。
