Liu Katy C, Cheney Richard E
Department of Cell and Molecular Physiology; School of Medicine; University of North Carolina at Chapel Hill; Chapel Hill, NC USA.
Bioarchitecture. 2012 Sep-Oct;2(5):158-70. doi: 10.4161/bioa.21791. Epub 2012 Sep 1.
The development of cell-cell junctions was a fundamental step in metazoan evolution, and human health depends on the formation and function of cell junctions. Although it has long been known that actin and conventional myosin have important roles in cell junctions, research has begun to reveal the specific functions of the different forms of conventional myosin. Exciting new data also reveals that a growing number of unconventional myosins have important roles in cell junctions. Experiments showing that cell junctions act as mechanosensors have also provided new impetus to understand the functions of myosins and the forces they exert. In this review we will summarize recent developments on the roles of myosins in cell junctions.
细胞间连接的发展是后生动物进化中的一个基本步骤，人类健康依赖于细胞连接的形成和功能。虽然长期以来人们都知道肌动蛋白和传统肌球蛋白在细胞连接中发挥着重要作用，但研究已开始揭示不同形式的传统肌球蛋白的具体功能。令人兴奋的新数据还表明，越来越多的非传统肌球蛋白在细胞连接中发挥着重要作用。表明细胞连接可作为机械传感器的实验也为理解肌球蛋白的功能及其施加的力提供了新的动力。在这篇综述中，我们将总结肌球蛋白在细胞连接中作用的最新进展。
